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The aim of the study was to compare efficacy and safety of Sarilumab ( Kevzara ) monotherapy with Adalimumab ( Humira ) monotherapy in patients with active rheumatoid arthritis who should not continue ...


In 2016, the National Institute for Health and Care Excellence ( NICE ) approved the use of Belimumab ( Benlysta ) for the treatment of autoantibody-positive systemic lupus erythematosus ( SLE ). I ...


FKB327 ( Hulio ) is a proposed biosimilar of the Adalimumab Reference Product ( RP; Humira ). A randomized, double-blind, phase 3 study compared the efficacy, safety, pharmacokinetics and immunogeni ...


Psoriatic arthritis ( PsA ) is an inflammatory arthropathy, associated with skin and/or nail psoriasis. Real world data on efficacy and safety of TNF-alpha blockers in the elderly with psoriatic art ...


A study has evaluated the effectiveness of oral Glucosamine in subgroups of people with hip or knee osteoarthritis ( OA ) based on baseline pain severity, body mass index ( BMI ), sex, structural abno ...


Results from the phase 3 SELECT-MONOTHERAPY clinical trial were announced. This ongoing study evaluated Upadacitinib ( ABT-494 ), an investigational oral JAK1-selective inhibitor, as a monotherapy t ...


Results from the phase 3 SELECT-BEYOND clinical trial evaluating Upadacitinib ( ABT-494 ), an investigational oral JAK1-selective inhibitor, in patients with moderate to severe rheumatoid arthritis wh ...


Results of the landmark PRECISION ( Prospective Randomized Evaluation of Celecoxib Integrated Safety vs Ibuprofen Or Naproxen ) trial demonstrated similar rates of cardiovascular risk in patients trea ...


New data showing Secukinumab ( Cosentyx ) delivers sustained improvements in the signs and symptoms of psoriatic arthritis over three years, including patient-reported pain, were presented at the 2016 ...


In a phase III, double-blind 24-week study, RA-BUILD, 684 biologic disease-modifying antirheumatic drug (DMARD)-naïve patients with rheumatoid arthritis and inadequate response or intolerance to grea ...


Anifrolumab is an investigational, fully human monoclonal antibody that binds to subunit 1 of the type I IFN receptor, inhibiting the activity of all type I IFNs, which play a central role in lupus, i ...


The results from the phase III study known as GiACTA, which evaluated Tocilizumab ( Actemra, RoActemra ), an anti-IL-6 receptor monoclonal antibody, in people with giant cell arteritis ( GCA ) were pr ...


Cardiovascular disease ( CVD ) is the leading cause of death in rheumatoid arthritis ( RA ) patients. This study is the first to report the association of Hydroxychloroquine ( Plaquenil; an antirheuma ...


IL-6 is one of the most abundant cytokines in the serum and synovial fluid of patients with rheumatoid arthritis ( RA ). In rheumatoid arthritis, IL-6 is synthesized and secreted by cells of the sy ...


Synovial joint damage is mediated by cells of the pannus. In rheumatoid arthritis, there is a marked increase in proliferation, or hyperplasia, of cells of the synovial intimal lining, which include f ...